Although sustained production of aldosterone requires persistent calcium entry through low-voltage activated Ca 2+ channels, isolated zona glomerulosa cells are considered nonexcitable, with recorded membrane voltages that are too hyperpolarized to permit Ca 2+ channels entry. In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin–angiotensin system. The zona glomerulosa is the outermost layer, below the renal capsule (near the pointer)
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